NICE recommends prucalopride for chronic constipation in women

NICE has recommended prucalopride as an option in certain circumstances for women with chronic constipation: treatment with at least two laxatives from different classes, at the highest tolerated recommended dose for at least six months, must have failed to provide adequate relief; and invasive treatment is being considered.

If prucalopride is not effective after 4 weeks, the woman should be examined again and the treatment reconsidered. Only clinicians with experience in treating chronic constipation should prescribe prucalopride, and they should review previous treatments carefully first.